Together with our partners, The Michael J. Fox Foundation we are the largest non-government funders of Parkinson’s research across multiple research institutes in Australia. Since we started in 2011 Shake It Up have invested over $3 million into Australian research in our pursuit to find a cure for Parkinson’s disease.
We have made good progress and are excited to share with you an innovative new clinical trial involving a range of new disease-modifying therapeutics aimed at slowing or stopping long-term neurodegeneration in patients with Parkinson’s disease.
The Australian Parkinson’s Linked Clinical Trials Program is an initiative of The Cure Parkinson’s Trust (UK), the Garvan Institute of Medical Research and the Shake It Up Australia Foundation.
Dependent on funding the Australian trials will choose between sixteen drugs already approved for use in humans, and will be included in the repurposing study which will significantly reduce the length of pre-clinical time required which means a faster outcome for patients.
An existing repurposing study is already underway at the University of Queensland (UQ) with a research team led by Dr Richard Gordon from The School of Biomedical Sciences investigating the potential of repurposing an existing blood pressure drug to slow or halt the progression of Parkinson’s disease. The drug has been prescribed for high blood pressure in a number of countries since the 1990s and has a good safety record for long-term use. This research study is evaluating if forms of the drug could block brain inflammation associated with the progression of Parkinson’s disease.
“There is accumulating evidence that patients develop chronic immune activation and brain inflammation due to the build-up of insoluble protein clumps called ‘Lewy bodies’ in Parkinson’s,” Dr Gordon said. “By halting the inflammation cycle, the drug could act as a potential therapeutic to halt or slow disease progression.”
I am very enthusiastic about the potential of the Linked Clinical Trials Program because we will not need to wait 10-15 years for the outcome of this research to benefit people living with Parkinson’s disease. This international collaboration will fast track outcomes for people living with Parkinson’s now and hopefully provide new hope for improved drug treatments to slow or halt the progression of Parkinson’s whilst we continue with our efforts to find a cure.
We need your help to raise an initial $1 million in funding this year to support research of the first four drugs in the Linked Clinical Trials Program.
Your donation of $2 or more is tax deductible so I urge you to donate before the 30 June to help us meet our fundraising goal. 100% of all donations will go to funding this program as all of our administration costs are covered by the Founding Directors. Your your donation will make a real difference. Thank you for your valued support.
Shake It Up Australia Founder