Screening the functional impact of environmental chemicals on human neurons and astrocytes in vitro

Parkinson’s Research Project Title:Screening the functional impact of environmental chemicals on human neurons and astrocytes in vitro

Principal Investigators: Professor Cedric Bardy

Institutions: Flinders University

Study Rationale:

Exposure to environmental chemicals—such as agricultural pesticides and industrial compounds—has been linked to an increased risk of Parkinson’s disease (PD). However, the mechanisms by which these chemicals impact human brain cells remain unclear. This study, led by Professor Cedric Bardy at Flinders University and SAHMRI, will investigate how these substances alter the electrical activity and function of human neurons and astrocytes, the key brain cells involved in PD.

Using induced pluripotent stem cell (iPSC) technology, researchers will generate dopamine-producing neurons—cells that are selectively lost in Parkinson’s disease—from both healthy individuals and PD patients. These neurons will be exposed to some of Australia’s most prevalent environmental chemicals under different conditions, including acute (minutes) and chronic (weeks) exposure at varying concentrations.

By analysing changes in neuronal firing activity, cellular function, and degeneration, the study aims to identify neurotoxic chemicals and their effects on brain health. This research will provide crucial evidence on how environmental exposures contribute to neurodegeneration, which could inform public health policies, regulatory standards, and safer chemical use in agriculture and industry.

Additionally, findings from this study may guide future therapeutic strategies to protect brain cells from environmental damage, ultimately reducing the burden of Parkinson’s disease and other neurodegenerative conditions.