Parkinson’s Research Project Title: Assessment of electrophysiological and mitochondrial phenotypes in neurons, astrocytes and microglia from SNCA triplication lines
Principal Investigators: Professor Lezanne Ooi
Institutions: University of Wollongong
Study Rationale:
In an exciting step forward for Parkinson’s disease research, Professor Lezanne Ooi and her team have been funded to study the impact of SNCA gene triplication—a common familial mutation associated with Parkinson’s. The study will investigate critical differences in the health and functionality of neurons, astrocytes, and microglia derived from individuals with this genetic variation.
Understanding how SNCA triplication affects these cells could help identify the best resources for future Parkinson’s research. The findings could improve how scientists model Parkinson’s disease and test therapeutic interventions.
The team will examine how SNCA triplication alters the health and function of neurons, astrocytes, and microglia using cutting-edge techniques. By comparing these cells with control samples, the research will reveal essential insights into cellular behaviors and disease mechanisms.
The outcomes will inform future research targeting new therapies and guide the development of models for testing potential treatments, providing vital resources for the Parkinson’s research community.