Donate
  • About Us
    • Our Vision, Mission & Values
    • About Clyde
    • Our MJFF partnership
    • Our Board
    • Our Patron
    • Our Ambassadors
    • Our Team
    • In The Media
    • Annual Report
  • Research
    • Our MJFF Partnership
    • Our Research Projects
    • Catalyst Programme velocity (CPv)
    • Research Trials
    • How We Fund
    • For Researchers
    • Research News
    • Research Forums
  • News
  • About PD
    • Symptoms of Parkinson’s
    • Treatments for Parkinson’s
    • Living with Parkinson’s
    • Sharing Your Diagnosis
    • Young Onset Parkinson’s
    • Genetics
    • Caregiver Information
    • Parkinson’s Stories
  • Trials
  • Contact
  • Get Involved
    • Fundraise for Parkinson’s
    • In Memory Donations
    • Bequest to Parkinson’s
    • Corporate Support
  • Donate
  • About Us
    • Our Vision, Mission & Values
    • About Clyde
    • Our MJFF partnership
    • Our Board
    • Our Patron
    • Our Ambassadors
    • Our Team
    • In The Media
    • Annual Report
  • Research
    • Our MJFF Partnership
    • Our Research Projects
    • Catalyst Programme velocity (CPv)
    • Research Trials
    • How We Fund
    • For Researchers
    • Research News
    • Research Forums
  • News
  • About PD
    • Symptoms of Parkinson’s
    • Treatments for Parkinson’s
    • Living with Parkinson’s
    • Sharing Your Diagnosis
    • Young Onset Parkinson’s
    • Genetics
    • Caregiver Information
    • Parkinson’s Stories
  • Trials
  • Contact
  • Get Involved
    • Fundraise for Parkinson’s
    • In Memory Donations
    • Bequest to Parkinson’s
    • Corporate Support
  • Donate
Common Link Across Different Causes of Parkinson’s
Friday, 7th October 2016

Parkinson’s is a variable disease — different in age of onset, experience of symptoms and cause — but a new study points to a potential common link.

“Finding a common mechanism behind different suspected causes of Parkinson’s suggests that there might also be a common means to measure, treat or cure it,” said Marco Baptista, PhD, MJFF director of research programs in an interview with Scientific American.

A study recently published in Cell Stem Cell identified dysfunction of the Miro protein and mitochondria (powerhouse of the cell that makes energy) as that shared mechanism.

The Michael J. Fox Foundation (MJFF) funded part of this study, led by Stanford University, which examined cells from people with a mutation in the LRRK2 gene, the greatest known genetic contributor to Parkinson’s disease (PD). The scientists found that both LRRK2 cells and cells from “sporadic” (cause unknown) PD showed Miro and mitochondria dysfunction.

Miro is taken away when mitochondria isn’t working well and needs to be recycled by the cell. LRRK2 dysfunction prevents that Miro removal, which slows the recycling process and may harm the cell.

These findings present another piece of the LRRK2 puzzle. Our Foundation is leading an effort to learn more about this top therapeutic target. Read more about another finding in this area.
And these results are a key example of how studying genetic dysfunction in PD — though not many cases are genetic — can uncover traits shared across the disease. Another example is how researchers discovered that clumps of the protein alpha-synuclein are in cells of nearly all people with PD by identifying mutations in the SNCA gene among a small group.

MJFF’s landmark biomarkers study, the Parkinson’s Progression Markers Initiative (PPMI), is studying people with LRRK2 mutations to learn more about this subset of Parkinson’s.

Find out more on the research projects we are funding in Australia including the PPMI Study.

Article Source:  The Michael J. Fox Foundation

SHARE THIS ARTICLE

Related Post

A ‘Milestone Moment’ for Parkinson’s: LRRK2 drug moves to next stage
LRRK2 Drug Trial Shows Promising Results
Glenda Halliday and Nic Dzamko Share their Research in Layman Terms
Shake It Up Foundation
ABN: 65 270 391 304
Contact Us
1300 361 803
enquiries@shakeitup.org.au
ADDRESS
To mail a cheque:
Shake it up Australia Foundation:
PO Box 710, Spit Junction NSW 2088
LINKS
  • About Us
  • Register Clinical Trials
  • Getting Involved
  • Our Research
  • About Parkinson’s
  • Contact Us
OUR COMMUNITY
ACNC Registered Charity
FAQS | PRIVACY POLICY | Website by
Copyright © 2023 Shake It Up Australia Foundation. All rights reserved