Award Date: September 2019
Duration: 12 Months
Institution: La Trobe University
Researchers: Paul Robert Fisher, BSc, MPhil, PhD, Andrew H. Evans, MD, FRACP
The goal of this study is to determine if differences in mitochondrial function in lymphoblastoid cells and/or PBMCs can reliably detect prodromal status in those with a high risk of conversion to PD. Previous studies had demonstrated a clear mitochondrial deficit after discriminate analyses when multiple different readouts were combined for analysis in PD subjects vs to controls. These parameters also did not change with time. The reviewer (Sam Hasson, Amgen) suggested additional experiments to determine if these readouts could serve as biomarkers in a PD prodromal cohort.