Award Date: September 2019
Duration: 18 Months
Institution: The Walter and Eliza Hall Institute of Medical Research
Researchers: David Komander, PhD, Grant Dewson, Guillaume Lessene
Defects in the protein parkin cause the loss of nerve cells in the brain and are responsible for many cases of young-onset Parkinson’s disease that develops before 50 years of age. We now understand how Parkin normally needs to change its shape to function, and how this fails to occur in patients with defects in this protein. We aim to generate chemicals that provoke defective parkin to change shape and re-activate it and to establish new drugs to treat young-onset Parkinson’s disease.