Research Forums

Join our monthly Virtual Research Forums to learn more about our research agenda and the studies we are currently funding.

Our founder Clyde Campbell will be hosting these forums each month where we will share regular updates on the current research we are funding, progress being made and new discoveries. Each month we will invite a guest research team to outline their study rationale, what they are hoping to achieve and any progress they have made.

There will also be an opportunity to ask questions of the researchers after their presentation.

 

November Research Forum

Professor David Komander from The Walter and Eliza Hall Institute

Early onset Parkinson’s disease (EOPD) with an age-of-onset <50 years, is commonly inherited pointing towards a genetic cause. Amongst the roughly 15 PARK genes that are mutated in EOPD, PINK1 and Parkin are frequently harbouring loss-of-function mutations. Research in the past decade has unveiled the role of PINK1 and Parkin in mitochondrial turnover, and our work has explained how PINK1 and Parkin are activated at the molecular level. Together, this has led to detailed molecular movies of the earliest steps of mitophagy, explaining how damaged mitochondria are tagged for destruction. The molecular movies have further enabled a clear view of where and how disease modulating small molecule drugs could act, and which patient subpopulations would benefit from such emerging treatments. Our Shake-It-Up / Michael J Fox Foundation funded project proposes to utilise the National Drug Discovery Centre to identify these targeted, first-in-class small molecules.

 

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