Our Research Projects

In the 2015/16FY The Shake It Up Australia Foundation/Michael J. Fox Foundation (MJFF) partnership has committed over $1.6M to Australian Parkinson’s research making us the largest non-government funder of Parkinson’s research in Australia.

Through our unique partnership we know this research is strategic, non-redundant and internationally competitive. Listed below are the projects we have funded and with your support we look forward to funding many more in the future.

Current projects

 

Pharmacological Targeting of Proinflammatory Kinase Signaling in Parkinson’s Disease

Dr Richard Gordon research into Parkinson's disease

Dr Richard Gordon

Award Date: November 2016

Duration: 12 months

Institution:  UQ’s School of Biomedical Sciences

Researchers:

  • Dr Richard Gordon
  • The research collaboration comprises researchers from across UQ, including Dr. Richard Gordon and Associate Professor Woodruff from the School of Biomedical Sciences, Dr John O’Sullivan from The School of Medicine and RBWH and Professor Matt Cooper and Dr Kate Schroder from the Institute for Molecular Bioscience.

Find out more

Blocking Inflammasome-induced Neuroinflammation in Parkinson’s Disease with a Potent, Orally Available Small Molecule

Matthew Cooper - receives funding from Shake It Up for Parkinson's research

Matthew Cooper, PhD

Award Date: September 2016

Duration: 12 months

Institution:  NHMRC Principal Research Fellow and Professor of Chemistry & Structural Biology at University of Queensland

Researchers:

  • Matthew Allister Cooper, PhD

Find out more

FLUROSCENCE TAGGING OF ENDOGENOUS LRRK2 TO ENABLE IN VIVO IMAGING IN MICE AND DIFFERENTIATED HUMAN IPS CELLS

Dzamko2

Dr Nicolas Dzamko

Award Date: March 2016

Duration: 12 months

Institution:  Neuroscience Research Australia

Researchers:

  • Nicolas Dzmako

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DEVELOPMENT OF A NOVEL TRACER FOR IMAGING A-SYNUCLEIN IN VIVO

Victor Villemagne

Award Date: March 2016

Duration: 12 months

Institution:  The Florey Institute of Neuroscience and Mental Health

Researchers:

  • Victor Villemagne, MD
  • Kevin Barnham, PhD

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UNDERSTANDING LRRK2 S910/S935 PHOSPHORYLATION IS IMPORTANT FOR THERAPEUTIC LRRK2 INHIBITOR DEVELOPMENT.

Dzamko2

Dr Nicolas Dzamko

Award Date: March 2016

Duration: 12 months

Institution:  Neuroscience Research Australia (NeuRA)

Researchers:

  • Nicolas Dzamko, PhD

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ARE THERE PERIPHERAL CHANGES IN GBA PROTEIN/ACTIVITY IN IDIOPATHIC PARKINSON’S DISEASE PATIENTS

Professor Glenda Halliday

Professor Glenda Halliday

Award Date: March 2016

Duration: 2 years

Institution:  Neuroscience Research Australia (NeuRA)

Researchers:

  • Professor Glenda Halliday

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MEASURING MITOCHONDRIAL RESPIRATION AND STRESS SIGNALLING IN BLOOD CELLS AS BIOMARKERS FOR PARKINSON’S DISEASE

L-R Emma Collin, Professor Paul Fisher, Dr Danuta Loesch-Mdzewska, Ben Young, Dr Sarah Annesley and Associate Professor David Finklestein

Award Date:  July 2015

Duration: 3 years

Institution:  La Trobe University

Researchers:

  • Professor Fisher
  • Dr Sarah Annesley
  • Dr Danuta Loesch-Mdzewska

Under an exciting new funding agreement with Parkinson’s Victoria we will see the Shake It Up component for this specific project shared equally with Parkinson’s Victoria.

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PHARMCOLOGICAL TARGETING OF THE NLRP3 INFLAMMASOME

Researchers from the University of Queensland.

Associate Professor Woodruff with fellow researchers

Award Date:  December 2014

Duration: 2 years

Institution:  University of Queensland

Researchers:

  • Associate Professor Woodruff

Find out more

 

Past projects

 

LRRK2 AND TYPE-1 INTERFERON

Dzamko2

Dr Nicolas Dzamko

Award Date: July 2014

Duration: 1 year

Institution:  Neuroscience Research Australia (NeuRA)

Researchers:

  • Professor Glenda Halliday
  • Dr Nicolas Dzamko

Find out more

 

 

VERIFICATION OF A LONG-NONCODING RNA IN BLOOD AS A BIOMARKER

Anthony Cooper - Garvan Institute

Associate Professor Antony Cooper

Award Date:  June 2014

Duration:  1 year

Institution:   Garvan Institute for Medical Research

Researchers:

  • John Mattick
  • Antony Cooper

Find out more

 

 

EFFECT OF LRRK2 MUTATIONS ON PD ASSOCIATED INFLAMMATION

Professor Glenda Halliday

Professor Glenda Halliday

Award Date:  February 2014

Duration:  1 year

Institution:  Neuroscience Research Australia (NeuRA)

Researchers:

  • Professor Glenda Halliday
  • Dr Nicolas Dzamko

Find out more

 

 

A BIOMARKER TEST FOR LRRK2 BLOCKING DRUGS

Professor Glenda Halliday and Dr Nicolas Dzamko

Professor Glenda Halliday and Dr Nicolas Dzamko

Award Date:  October, 2013

Duration:  1 year

Institution:  Neuroscience Research Australia (NeuRA)

Researchers:

  • Professor Glenda Halliday
  • Dr Nicolas Dzamko

Find out more

 

 

PARKINSON’S PROGRESSION MARKERS INITIATIVE (PPMI)

Professor Dominic Rowe

Professor Dominic Rowe

Award Date: April 2012

Duration:  5 years

Institution:  Macquarie Neurology at Macquarie University Clinic,  Macquarie University, Sydney, NSW

Researcher

  • Professor Dominic Rowe

Find out more

 

 

 

THE ROLE OF LONG NON-CODING RNAs IN PARKINSON’S DISEASE

Professor John Mattick

Professor John Mattick

Award Date:  September, 2013

Duration:  1 year

Institution:   Garvan Institute for Medical Research

Researchers:

  • John Mattick
  • Antony Cooper

Find out more

 

 

 LRRK2 EXPRESSION IN POST MORTEM BRAIN

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Professor Glenda Halliday and Dr Nicolas Dzamko

Award Date:  September 2013

Duration:  18 month

Institution:  Neuroscience Research Australia (NeuRA)

Researchers:

  •  Prof Glenda Halliday
  • Dr Nic Dzamko

Find out more

 

 

IMPROVING THERAPEUTIC TARGETING OF DOMPAMINERGIC AFFERENTS

Dr Catherine Leamey, Dr Atomu Sawatari

Award Date:  June 2013

Duration:  1 year

Institution:   University of Sydney

Researchers:

  • Atomu Sawatari
  • Catherine Anne Leamey

Find out more

 

 

ALPHA-SYNUCLEIN AS A MAJOR REGULATOR OF IRON

Associate Professor David Finklestein

Associate Professor David Finklestein

Award Date: October 2012

Duration:  2 years

Institution: Florey Institute for Neuroscience and Mental Health,

 

Researchers:

  • Scott Ayton, PhD, Melbourne , Australia
  • David I. Finkelstein, PhD Melbourne , Australia
  • Ashley I. Bush, MD/PhD Melbourne , Australia

Find out more

 

 

IS THE XENOMITOCHONDRIAL MOUSE AN ‘IDEAL’ PD MODEL

Dr Ian Andrew Trounce

Dr Ian Andrew Trounce

Award Date: March 2012

Duration: 1 year

Researchers:

  •  Ian Andrew Trounce, PhD – Center for Eye Research Australia
  • Zane Andrews, PhD -Neuronal Metabolism and Degeneration Lab
  • David Moses MD, FRACP -Department of Clinical Neuroscience and Neurological Research

Find out more

 

 

LRRK2 PHYSIOLOGY IN PARKINSON’S DISEASE

Professor Glenda Halliday and Dr Nicolas Dzamko

Professor Glenda Halliday and Dr Nicolas Dzamko

Award Date:   November 2011

Duration: 1 year

Institution:  Neuroscience Research Australia (NeuRA)

Researchers:

  •  Prof Glenda Halliday
  • Dr Nic Dzamko

Find out more

 

 

For further information on our research projects please contact us at enquiries@shakeitup.org.au or call us on 1300 361 803