Archives: Projects
Parkinson’s Research Project Title: Quantitative Mapping of aSyn soluble (monomers, oligomers) and insoluble PTMs in selected brain regions and cell...
Parkinson’s Research Project Title: Australian Parkinson’s Genetic Study (Year 2)
Principal Investigators: Miguel E. Renteria, PhD
Institution...
Parkinson’s Research Project Title: Longitudinal validation of peripheral lysosomal GCase under clinical trial conditions
Principal Investigator...
Parkinson’s Research Project Title: Investigation of disease- and pathogen-specific immune dysfunction traits in human PBMCs
Principal Investigators...
Parkinson’s Research Project Title: Neuroscience Clinical Trial Unit
Principal Investigators: Dr Kelly Bertram
Institutions: Alfred Health
Study Rat...
Project Title: Enhancing brain clearance mechanisms to limit Parkinson’s disease progression
Principal Investigators: Jason Howitt, PhD; Laura J...
Project Title: Characterising regiospecific lipid phenotypes in human PD and Gaucher tissues using next-generation MSI and IMS
Principal Investigators...
Professor Sue and her team have discovered that the Nix protein restores mitophagy and mitochondrial function in people with the PINK1/PARKIN gene mut...
Principal Investigator: Dr. Linlin Ma, Griffith University
Co-Principal Investigators: Dr. Ernst Wolvetang, The University of Queensland
Project Summ...
Researcher: Professor Melanie Bahlo PhD FAHMS
Institution: The Walter and Eliza Hall Institute of Medical Research
Study Rationale: Both genetic mutat...
Principal Investigator(s): Dr Tony Reid, Dr Bryan Oronsky and Dr Richard Gordon
Project Title: Validation of RRx-001 as a novel disease-modifying ther...
Rationale – The Global Parkinson’s Genetics Program (GP2) will genotype 200,000 volunteers around the world to further understand the genetic ...
Study Rationale: Persistent activation of the immune cells that reside in the brain leads to a state of chronic inflammation that contributes to the ...
Working in collaboration with the University of Auckland this project builds on previous findings specifically looking at single nucleotide polymorphi...
Sitala is a biotech company driving translational research into new therapies that will block harmful inflammation to help people living with Parkinso...
PINK1 and Parkin (PRKN) proteins are both involved in mitochondrial quality control, and loss-of-function mutations causing familial forms of PD with ...
How does the science work?
Associate Professor Cedric Bardy’s (Flinders University – SAHMRI) study uses live human neurons (brain cells) in a petr...
Study Rationale: Persistent activation of the immune cells that reside in the brain leads to a state of chronic inflammation that contributes to the ...
Study Rationale:
Gut dysfunction and microbiome dysbiosis have been linked to the onset and progression of PD pathology. However, the mechanisms by wh...
Study Rationale:
In Parkinson’s disease (PD) immune cells in the brain, gut and blood become persistently activated due the accumulation of synucle...
Study Rationale:
Chronic sleep disruption is among the most frequently reported and disabling pathological features of Parkinson’s disease (PD)....
Antisense oligonucleotides (ASOs) offer a new therapeutic strategy in Parkinson’s disease (PD) because they can be readily targeted to genes causall...
Study Rationale:
Glycosphingolipids are natural cellular fats. They are components of cellular membranes that fulfill multiple functional roles, from ...
Study Rationale:
Inflammasomes are large multiprotein complexes that play a central role in the innate immune system, the body’s first line of defen...
Award Date: July 2020
Duration: 36 Months
Institution: Queensland University of Technology
Researchers: Beatrix Karoline Feigl, MD, PhD
Non-motor ...
Award Date: July 2020
Duration: 12 months
Institution: University of New South Wales
Researchers: Yann GAMBIN, PhD
Study Rationale:
Pathogenic alp...
The goal of this study is to determine the effect of LRRK2 and GBA mutations on activities of both enzymes under basal/stimulated (pathogens) conditio...
Study Rationale:
Repetitive DNA elements such as “jumping genes” were previously considered ‘junk DNA’. However, it is now known that these el...
Study Title:
Astroglial proteins associated with astroglial alpha-synuclein in different stages of Parkinson’s disease
Study Rationale:
In addition ...
Principal Investigator(s):
Professor Paul R. Fisher, Dr. Andrew H. Evans, Dr. Danuta Z. Loesch-Mdzewska, Prof. E. Storey, Dr. Sarah J. Annesley
Projec...
Study Rationale:
Defects in the protein parkin cause the loss of nerve cells in the brain and are responsible for many cases of young-onset Parkinson&...
Project Summary
Evaluate if improved sleep and circadian rhythms resynchronization can protect against neuropathological features associated with slee...
Project Summary
This project characterizes a highly novel, promising new target where compelling data supports our argument that wildtype SOD1 pr...
Project Summary
This project will leverage digital spatial profiling technology to examine multiple molecular targets on immune-oncology pathways at d...
A clinical trial looking at constipation and gut dysfunction is now underway at the University of Queensland. The trial will determine if a targeted t...
Shake It Up Australia together with our partners at The Michael J. Fox Foundation have committed funding to Professor Andrew Hill at La Trobe Universi...
Researchers from The University of Queensland will investigate the potential of existing drugs to be repurposed to fight Parkinson’s disease thanks ...
The Michael J. Fox Foundation and the Shake It Up Australia Foundation for Parkinson’s Research (MJFF & SIUAF) have funded a grant at NEURA to t...
An emerging hypothesis is that LRRK2 and GBA converge on certain intracellular pathways such as lipids, lysosomes and inflammation. If experimentally ...
This project seeks to demonstrate that the use of targets will identify PwP with uncontrolled motor features of PD and that treating these subjects a...
Award Date: February 2017
Duration: 12 months
Institution: The University of Sydney
Researchers: Dr Nicolas Dzamko PhD
Study Rationale:
A gro...
Study Rationale:
Differences in the leucine-rich repeat kinase 2 (LRRK2) gene can increase the risk of developing Parkinson’s disease (PD), and ther...
The research team at QLD University
Study Rationale:
Our brains are full of immune cells called microglia, which fight infections and clear the brain ...
Project details
Researchers: Victor Villemagne, MD and Kevin Barnham, PhD
Institution: The Florey Institute of Neuroscience and Mental Health
Grant ...
Researcher: Professor Glenda Halliday
Co-principal Investigators: Associate Professor Simon Lewis, Associate Professor John Kwok & Dr Nicolas D...
Funding of this project reflects Shake It Up and MJFFs ongoing commitment to the talent of the team at NeuRA and their ability to answer some of the k...