Archives: Projects

Principal Investigator: Dr. Linlin Ma, Griffith University Co-Principal Investigators: Dr. Ernst Wolvetang, The University of Queensland Project Summ...
Researcher: Professor Melanie Bahlo PhD FAHMS Institution: The Walter and Eliza Hall Institute of Medical Research Study Rationale: Both genetic mutat...
Principal Investigator(s): Dr Tony Reid, Dr Bryan Oronsky and Dr Richard Gordon Project Title: Validation of RRx-001 as a novel disease-modifying ther...
Rationale – The Global Parkinson’s Genetics Program (GP2) will genotype 150,000 volunteers around the world to further understand the genetic ...
Study Rationale: Persistent activation of the immune cells that reside in the brain leads to a state of chronic inflammation that contributes to the ...
Working in collaboration with the University of Auckland this project builds on previous findings specifically looking at single nucleotide polymorphi...
Sitala is a biotech company driving translational research into new therapies that will block harmful inflammation to help people living with Parkinso...
PINK1 and Parkin (PRKN) proteins are both involved in mitochondrial quality control, and loss-of-function mutations causing familial forms of PD with ...
How does the science work? Associate Professor Cedric Bardy’s (Flinders University – SAHMRI) study uses live human neurons (brain cells) in a petr...
Study Rationale: Persistent activation of the immune cells that reside in the brain leads to a state of chronic inflammation that contributes to the ...
Study Rationale: Gut dysfunction and microbiome dysbiosis have been linked to the onset and progression of PD pathology. However, the mechanisms by wh...
Study Rationale: In Parkinson’s disease (PD) immune cells in the brain, gut and blood become persistently activated due the accumulation of synucle...
Study Rationale: Chronic sleep disruption is among the most frequently reported and disabling pathological features of Parkinson’s disease (PD)....
Antisense oligonucleotides (ASOs) offer a new therapeutic strategy in Parkinson’s disease (PD) because they can be readily targeted to genes causall...
Study Rationale: Glycosphingolipids are natural cellular fats. They are components of cellular membranes that fulfill multiple functional roles, from ...
Study Rationale: Inflammasomes are large multiprotein complexes that play a central role in the innate immune system, the body’s first line of defen...
Award Date: July 2020 Duration: 36 Months Institution: Queensland University of Technology Researchers: Beatrix Karoline Feigl, MD, PhD Non-motor ...
Award Date: July 2020 Duration: 12 months Institution: University of New South Wales Researchers: Yann GAMBIN, PhD Study Rationale: Pathogenic alp...
The goal of this study is to determine the effect of LRRK2 and GBA mutations on activities of both enzymes under basal/stimulated (pathogens) conditio...
Study Rationale: Repetitive DNA elements such as “jumping genes” were previously considered ‘junk DNA’. However, it is now known that these el...
Study Title: Astroglial proteins associated with astroglial alpha-synuclein in different stages of Parkinson’s disease Study Rationale: In addition ...
Principal Investigator(s): Professor Paul R. Fisher, Dr. Andrew H. Evans, Dr. Danuta Z. Loesch-Mdzewska, Prof. E. Storey, Dr. Sarah J. Annesley Projec...
Study Rationale: Defects in the protein parkin cause the loss of nerve cells in the brain and are responsible for many cases of young-onset Parkinson&...
Project Summary Evaluate if improved sleep and circadian rhythms resynchronization can protect against neuropathological features associated with slee...
Project Summary This project characterizes a highly novel, promising new target where compelling data supports our argument that wildtype SOD1 pr...
Project Summary This project will leverage digital spatial profiling technology to examine multiple molecular targets on immune-oncology pathways at d...
A clinical trial looking at constipation and gut dysfunction is now underway at the University of Queensland. The trial will determine if a targeted t...
Shake It Up Australia together with our partners at The Michael J. Fox Foundation have committed funding to Professor Andrew Hill at La Trobe Universi...
Researchers from The University of Queensland will investigate the potential of existing drugs to be repurposed to fight Parkinson’s disease thanks ...
The Michael J. Fox Foundation and the Shake It Up Australia Foundation for Parkinson’s Research (MJFF & SIUAF) have funded a grant at NEURA to t...
An emerging hypothesis is that LRRK2 and GBA converge on certain intracellular pathways such as lipids, lysosomes and inflammation. If experimentally ...
This project seeks to demonstrate that the use of targets will identify PwP with uncontrolled motor features of PD and that treating these subjects a...
Award Date: February 2017 Duration: 12 months Institution: The University of Sydney Researchers: Dr Nicolas Dzamko PhD Study Rationale: A gro...
Study Rationale: Differences in the leucine-rich repeat kinase 2 (LRRK2) gene can increase the risk of developing Parkinson’s disease (PD), and ther...
The research team at QLD University Study Rationale: Our brains are full of immune cells called microglia, which fight infections and clear the brain ...
Project details Researchers: Victor Villemagne, MD and Kevin Barnham, PhD Institution: The Florey Institute of Neuroscience and Mental Health Grant ...
Researcher: Professor Glenda Halliday Co-principal Investigators:  Associate Professor Simon Lewis, Associate Professor John Kwok & Dr Nicolas D...
Funding of this project reflects Shake It Up and MJFFs ongoing commitment to the talent of the team at NeuRA and their ability to answer some of the k...
On Monday 11 April, Shake It Up Australia and Parkinson’s Victoria announced their firm commitment to work together in the area of research funding ...
Shake It Up has committed to a research project at University of Queensland focused on inflammation. To give you a better understanding of this resear...
Shake It Up Australia Foundation is delighted to be funding more world leading research at Neuroscience Research Australia (NeuRA). The twelve month r...
Shake It Up Australia recently launched an opportunity for its supporters to help fund a world leading research opportunity at The Garvin Institute of...
Shake It Up Australia Foundation is delighted to announce new funding for world’s best research being conducted at Neuroscience Research Australia (...
Since establishment in 2011 Shake It Up has committed over $1M to Parkinson’s research in Australia. Through our partnership with The Michael J. Fox...
The Michael J. Fox Foundation for Parkinson’s Research and Shake It Up Australia Foundation are co-funding a 12-month research project by Sydney’s...